2012 Vol. 18 Nr 2 - TIDNINGEN


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Ten milliliters of iohexol (6.47 g) was injected into the marginal auricular vein and blood 2019-11-14 Plasma clearance of iohexol was evaluated in eight anesthetized California sea lions (Zalophus californianus), without evidence of renal dysfunction, to determine if the one-compartment model and the sample protocol used in dogs and cats could be applied to this species. Nonlinearity between samples in 75% (6/8) of sea lions voided those results. 2015-06-04 Iohexol is very stable in serum, but we would recommend that any samples sent from outside the UK are shipped chilled or frozen to allow for the longer delivery time. References and links Finch NC, Syme HM, Elliott J, Peters AM, Gerritsen R, Croubels S, Heiene R. (2011) Glomerular filtration rate estimation by use of a correction formula for slope-intercept plasma iohexol clearance in cats. Rör utan tillsats (rör propp) Hela belastningen (injektion av iohexol oxh provtagning) utförs av Klinisk kemi Västerås, njurmedicin Köping eller barnkliniken Västerås. Kommentar/ Viktigt att veta. Kan ej utföras vid allergi mot röntgenkontrastmedel (Omnipaque) eller inom en vecka efter utförd kontraströntgenundersökning.

Iohexol clearance protocol

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In 1984, we introduced iohexol clearance as a method for the determination of glomerular filtration rate (GFR) in clinical work (4). Since then, we have used the method extensively in experimen-tal medicine, and since 1988 it is the standard method for GFR measurements at our hospital. Iohexol clearance is now performed by at least 30 På förmiddagen ges en injektion av Iohexol via en venflon. Ett eller flera blodprov tas efter 3–5 timmar, men vid kraftigt sänkt njurfunktion (förväntat värde <20ml/min tas provet dagen efter. Tidsåtgång 4–5 timmar. Vid provtagning dagen efter, tidsåtgång: dag 1 ca 30 min, dag 2 ca 15 min.

2012 Vol. 18 Nr 2 - TIDNINGEN

Following a single injection, iohexol concentration in plasma falls as a result of both distribution and elimination. 2003-01-17 The mGFR will be obtained by the assessment of nonradioactive iohexol clearance. Patients previously enrolled in the SCOPE study, are invited to participate in this additional protocol. Iohexol is an iodinated contrast medium with characteristics similar to those of inulin, being freely filtered by the glomerulus, neither secreted nor reabsorbed by the renal tubules and recovered almost 100% 2.2 | Iohexol clearance protocol A standard protocol was used for performing the iohexol clearance tests via a limited sampling technique.23 Asingledoseofiohexol (Omnipaque™ 300) was administered at 300 mg iodine/kg intrave-nously through an IV catheter.

Iohexol plasma clearance for measuring glomerular filtration

Plasma clearance is determined after intravenous administration of 5–10 mL of the pharmacological preparation and subsequent multiple sample drawings, according to different schedules or even with single specimen protocols. Iohexol in biological matrices is readily determinable, with sufficient sensitivity and specificity by means of the most commonly used analytical technologies: sample preparation is fast and the compound is quite stable in biological samples, either at room temperature Background Iohexol clearance is an accurate and precise exogenous marker of glomerular Þltration rate (GFR), but protocols are generally lengthy or require multiple sampling. Shorter or simpler protocols would be more practicable. Methods Two clearance estimates, two weeks apart, were undertaken in 11 The mGFR will be obtained by the assessment of nonradioactive iohexol clearance. Patients previously enrolled in the SCOPE study, are invited to participate in this additional protocol.

contrast agent where a diagnostic procedure is thought essential, but caution should iohexol levels indicate that the iohexol body clearance is due primarily to  Key words: glomerular filtration rate, measurement, iohexol, recommendations, Plasma clearance measurement is the protocol of choice: single-sample  Animals—4 renal-intact and 6 partially nephrectomized adult cats.
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också uppskattas från patientens protocol; those able to walk between 150 and 425 m were assigned. either to the moderate-heart-failure  Pressure in relation to Cardiovascular Outcome (IDACO): protocol and plasma cystatin C shows strong agreement with iohexol clearance in patients with low  become an adopted protocol in routine prenatal diag- nosis in several iohexol clearanse . Eftersom och Krom- EdTA clearance minskar stadigt .

This iohexol distribution pattern applies also to patients with CKD and obese subjects [ 22–26 ]. Iohexol plasma clearance for measuring glomerular filtration rate in clinical Plasma clearance measurement is the protocol of choice as it combines a reliable GFR determination with 2003-01-17 · The total plasma disappearance of iohexol was measured by x-ray fluorescence analysis and the clearance was calculated. The (99m)Tc-DTPA clearance was determined in accordance with a standard protocol.
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